Homework Coursework Example | Topics and Well Written Essays - 250 words - 8

Homework - Coursework Example There was a gradual escalation and then the South Vietnamese executed members of the secret police. Kennedy did not change his policies. 2. How did Johnson â€Å"Americanize† the war in Vietnam, and how effective was this strategy? Johnson did not want the reputation of the country to suffer by continuing involvement with Vietnam. But he did order air strikes on North Vietnam after hearing that North Vietnam military had fired on U.S. ships. He continued support to South Vietnam and the U.S. military became more aggressive. Military and economic assistance to the government and military of South Vietnam continued. Instead of Johnson having a defensive military presence, he changed it so that it was more of an offensive approach. Some of that pressure was also coming due to approaching presidential elections. 3. What different strategies and criticisms of society were offered by mainstream and radical feminists? (CH28) During Johnson’s time in office, he created a lot of reform that helped bring people out of poverty that helped male-headed households but worsened female-headed households. Many civil rights groups were created to protest Johnson’s changes. There were several new movements during this time so feminists could accomplish goals of equality. Women were involved in changing the collegiate environment so that there would be more religious studies programs. Women that were lesbians began a movement so that they no longer had to keep their sexuality hidden and there was a Stonewall Riot that resulted in more attention to gay rights. More women began to take jobs. Women realized their opportunities were not equal and they began to go to school more. The National Organization for Women was created for more civil rights for women and there was an investigation in the w orkplace where the Equal Pay Act of 1963 made it illegal to pay women less than men for the same

Annual Rreport Analysis Coursework Example | Topics and Well Written Essays - 1000 words

Annual Rreport Analysis - Coursework Example More significantly, financial analysis measures the financial performance of a company as in terms of profitability and investment ratios in its operations. As a result, financial analysis of a company, through the financial ratio allows the management to carry out both firms performance and the trend analysis performance for specific years. Sources of Finance More than often, companies have to seek sources of financing requires funds to purchase fixed assets, to finance growth and expansion and to increase its working capital. Nevertheless, these sources of long-term financing are not easily accessible because they include a fixed term contract and large amounts of fund (Brigham & Ehrhardt, 2011). As a result, companies opt to raise long-term capital by issuing shares to shareholders from the public. There are two types of shareholders including equity shareholders who are directly involved in company affairs and the preference shareholders who are entitled to profits before equity shareholders (Davies & Pain, 2011). In addition, companies can use long-term loans as sources of finance from financial institutions. These loans could either be from government or private financial institutions who give long-term loans at reasonable rate of interest and repayment period (Gowthorpe, 2011). More so, the companies can use debentures as there sources of finance that are issued to the public. ... Financial Analysis of TCB bank and Bank of Georgia As financial services provider institutions, both the TCB bank and Bank of Georgia seek these sources of long-term finance to increase their business lines and boost their working capital. As a result, the two companies have shareholders both equity and the preference shareholders who are entitled to profits from the company’s proceedings. In addition, the financial institutions use debentures as there sources of finance from the public who make up the creditors of the companies (Nikolai, Bazley & Jones, 2010). As other financial institutions, the two companies source out for long-term loans as sources of finance from other financial institutions within reasonable rate of interest and repayment period. In addition, the two companies have funds from their retained earnings as sources of long-term finance (Fields, 2011). 1) Profitability Ratio 2011 2010 Return on assets= Net income/ = 91,625 /2783901=0.033 49,435/2002900.5=0.025 TCB Bank Total average asset Return on assets= Net income/ = 138973/ 4182165=0.033 78043/ 4004922=0.019 Bank of Georgia Total average asset Return on equity=Net income/ = 91,625 / 423026.5 =0.217 49,435/352007.5=0.140 TCB Bank Average stockholders’ equity Return on equity=Net income/ = 138973/918677.5=0.151 78043/812,603=0.096 Bank of Georgia Average stockholders’ equity Net Profit margin= Net Income/ Sales = 91,625 /209,081=0.438 49,435/162,814=0.304 TCB Bank (TCB Bank, 2012) Net Profit margin= Net income/ Sales = 138973/360,215=0.386 78043/413673=0.189 Bank of Georgia Gross Profit margin= Gross Income/ Sales = 209,081/ 360,215=0.580 162,814/ 271,805=0.600 TCB Bank Gross

Should college athletes be paid Essay Example | Topics and Well Written Essays - 1000 words

Should college athletes be paid - Essay Example For quite some time, there has been an extensive debate over payment of athletes, with each party in the debate presenting valid opinions that cannot be overlooked. It is essential to consider both the pros and cons of paying the athletes in order to come up with an objective decision. It is no secret that athletes earn their relative institutions high amounts of revenue. College athletes generate millions of dollars for their colleges and are required to be content with scholarships they enjoy (Griffin 19). This beats the principle of equity, and the athletes are, therefore, entitled to the revenue they generated. Athletes are exposed to risks that pertain to health, arising from the setting and nature of games and sports they take part in. These athletes, all around the young age of 22 or so, end their college careers with injured bodies, muscles that have repeatedly been shot up with cortisone injections, conditions such as prediabetes and prehypertension, and - in the case of the linemen - waistlines of 45 to 50 inches. The average career for a NFL player is only a few years, depending on the position. Early injuries in the transition from college to professional are a substantial reason, given that they have often compromised their bodies and health just to reach the NFL in the first place. This presents a case to pay college athletes to compensate them for the risks they face and also so that they can be able to access best medical care as well as have a balanced diet (Griffin 43). To be successful in any athletic competition, considerable investment of time and effort is paramount. This forces athletes to sacrifice their time in college and ensure that they adequately train in order to enhance their talent and give them a competitive edge. They do so while ensuring that they do not neglect their academic work, at times creating study time tables so as to be at par with their classmates, which creates an extra strenuous

21st Century Student Observation Essay Example for Free

21st Century Student Observation Essay While observing middle school, high school and college age students at a local mall, I was taken aback by the differences in styles and attitudes from when I attended those various levels of education. I observed and noted many attributes and behaviors of these various peer groups and notice some similarities and some differences between each group. The peer group, which consists of friends who are of approximately the same age and social status, is one of the most important institutions for shaping a child’s social behavior (Webb, Cite). Although some social stereotypes where confirmed, others where surprisingly disproved. The first behavior that I studied was the communication styles and verbiage of each peer group. The most glaring similarity that I found amongst most of the students I observed was the improper use of the English language. The word that was used incorrectly the most was the word â€Å"like. † It was used in almost every sentence that was spoken between the different peer groups and almost every time it was spoken it was said between words i. e. I was like†¦ and he was like†¦Ã¢â‚¬  This form of communication has spanned a generation, however because this misuse was very common when I was growing up and progressively weakened as I aged. The other form of communication that I observed was that of the text message. I was surprised by how much each peer group used texting to communicate with each other. I observed that text messaging has replaced normal conversation amongst every age group. Generations have been dealing with changes in technology for decades but the integration of the cell phone into our society has dramatically changed the way that children communicate between each other. The second observation that I noted was that of the interpersonal skills that each peer group demonstrated. The younger the children, the more physical interactions took place. The younger boys would rough house with each other whereas the older boys tended to interact using verbal or technological (texting) means. It seemed that each peer group lacks the more basic social/interpersonal skills that were more common to me as a child. I attest this to the use of technology as a means of communication rather than face to face conversations. The next observation I made was to document the types of discussions that each peer group were involved in. Across each group, most conversations were tied to the social calendar that each group was following. However, I did observe some of the college students discussing the issue of the convicted murderer who was recently released so that he may be retried. This is a hot topic issue in our community and I was surprised to find some adolescents having a serious discussion on this particular issue. The final observation was that of each peer group’s attitudes, attire and body art. This area was very random due to the different social groups that were observed. There was a large group of teenage girls that were congregating in the food court of the mall that were observed as very bubbly and seemed to be very carefree. As soon as a small group of teenagers that were dressed in the â€Å"emo† style (black clothes, many piercings, and tight jeans) moved into the food court, the mood of the teenage girls changed to a more subdued attitude. They become quiet and left their seats soon after the other group sat in the same vicinity. This was a very stereotypical judgment against these teens that were no different save their outward appearance. These teens sat down and began a bible study amongst the group. The observation of these students body art was difficult due to the fact that it is winter in Montana and most people were pretty bundled up. I did, however, observe many of the teenage girls having numerous piercing not only in their ears but in the faces, lips and noses. In observing today’s teenage students in a social setting, I found many similarities to my youth but also many glaring differences. I did observe some of the adults that interacted with these students as well and noted that many of the older generations gave long, disapproving glances to the students with numerous piercings and outlandish attire. I was discouraged by this behavior because we live in a society that allows us the freedom of expression and I have always felt that a person should be judged not by their appearance but the content of their character. I do feel that this activity has given me a better view of the student body that is prevalent in my community.

Techniques For Invitro Pharmacology Lab Report Biology Essay

Techniques For Invitro Pharmacology Lab Report Biology Essay Schild plot: Schild plot is defined as pharmacological method of receptor classification. By using schild plot dose-effect curve for an agonist is determined in the presence of various concentrations of a competitive antagonist for its receptor in the presence of agonist i.e. equilibrium dissociation constant is calculated. The experiment is carried out for series of dose ratios for a given effect. For example the ratio of the dose of agonist (A) to produce a specific effect (e.g.,  half maximal effect) in the presence of the antagonist (B) to the dose required in the absence of the antagonist (A) is calculated. This is determined for several doses of antagonist and then log ((A/A) -1) versus the negative log B is plotted.   If the regression of log ((A/A) -1) on -log B is linear with a slope of -1, then this indicates that the antagonism is competitive and by definition the agonist and antagonist act at the same recognition sites. If the slope of the regression is not -1, then b y definition the antagonist is not competitive or some other condition is in effect. This might include multiple binding sites or pharmacokinetic interactions. Agonist: Agonist is a drug which has both affinity and efficacy. Antagonist: Antagonist is a drug which has affinity and zero efficacy. Affinity:  Affinity is a property of a drug; it measures how tight a drug binds to a receptor. To bind to a receptor a functional group of the drug should bind to the complementary receptor. The binding capacity of the drug defines the action of the drug. Efficacy: Efficacy of a drug can be defined as ability of drug which activates the receptor to produce desired effect after binding. Affinity and efficacy are explained in the equation as: K+1 ÃŽ ± A + R AR* Response K-1 ÃŽ ² K+1 B + R BR No Response K-1 Where A is agonist, B is antagonist, K+1 is association rate constant for binding, K-1is dissociation rate constant for binding ÃŽ ±- Association rate constant for activation ÃŽ ²- Dissociation rate constant for activation By using law of mass action affinity is explained as B + R BR Drug free receptor drug-receptor complex At equilibrium KB = [R] [B] KB = Equilibrium dissociation constant [BR] Hill-Langmuir equation: this equation explains drug occupancy [RT] = [R] + [BR] If [RT] = Total number of receptors then by substituting this in law of mass action equation [RB] = [B] [RT] KB + [B] By this equation it is determined that drug occupancy (affinity) depends on drug concentration and equilibrium dissociation constant. Equilibrium dissosciation constant: EQUILIBRIUM DISSOCIATION CONSTANT (Kd) : It is the characteristic property of the drug and the receptors. It is defined as the concentration of the drug required to occupy 50 % of the receptors. The higher the affinity of the drug for the receptors lower is the Kd value. Mathematically Kd is k2/k1 where k2 is the rate of dissociation of the drug from the receptor and k1 is the rate of association of the drug for the receptor. Receptor (R) and Drug (D) interact in a reversible manner to form a drug-receptor (RD) complex.   Ã‚  Ã‚  Ã‚  Ã‚  Where R =   Receptor   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  D =   Drug (L for ligand is sometimes used in these equations)   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  k1 = the association rate constant and has the units of M-1min-1   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  k2 = the dissociation rate constant and has the units of min-1.     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  k2 is sometimes written as k-1. If an agonist binds to the receptor, then the interaction of the agonist (D) and the receptor (R) results in a conformational change in the receptor leading to a response. If an antagonist binds to the receptor, then the interaction of antagonist (D) and receptor (R) does not result in the appropriate conformation change in the receptor and a response does not occur. For drugs that follow the law of simple mass action the rate of formation of the complex can be defined by the following equation d[RD]/dt refers to the change in the concentration of [RD] with time (t). Note: the square brackets refer to concentration. This equation indicates that the rate at which the drug receptor complex (RD) is formed is proportional to the concentration of both free receptor (R) and free drug (D). The proportionality constant is k1. The rate of dissociation can be defined by the following equation -d[RD]/dt is the decrease in drug-receptor complex with time This equation indicates that the rate at which the drug-receptor complex (RD) dissociates back to free drug and free receptor is proportional to the concentration of the drug receptor complex. The proportionality constant is k2. When the drug and the receptor are initially mixed together, the amount of drug-receptor complex formed will exceed the dissociation of the drug-receptor complex. If the reaction is allowed to go for a long enough, the amount of drug-receptor complex formed per unit time will be equal to the number of dissociations of drug-receptor complex per unit of time, and the system will be at equilibrium. That is equilibrium has occurred.    Equilibrium can be defined as or k1[R][D] = k2[RD] This equation can be rearranged to give By definition Kd is the dissociation equilibrium constant. Kd has units of concentration as shown in the following equation. Simple competitive antagonism: simple competitive antagonism is the most important type of the antagonism. In this type of antagonism the antagonist will compete with available agonist for same receptor site. Sufficient antagonist will displace agonist resulting in lower frequency of receptor activation. Presence of antagonist shifts agonist log dose response curve to right. A schild plot for a competitive antagonist will have a slope equal to 1 and the X-intercept and Y-intercept will each equal the  dissociation constant  of the antagonist. This can be explained in equation as: Occupancy for agonist [RA] = [A] OR [A]/ KA [RT] KA+ [A] [A]/ KA +1 In presence of competitive antagonist (B) [RA] = [A]/ KA [RT] [A]/ KA + [B]/ KB + 1 Occupancy reduced according to [B] and KB To obtain same occupancy, must increase [A] to [A`] r = [A] / [A] = [B] / [B] Schild equation: r = [B] / KB +1 Where r depends on [B] and KB Applying log on both sides log (r-1) = log[B] log KB Aim: The main aim of the experiment is to measure the equilibrium dissociation constant (KB) for atropine at acetylcholine muscuranic receptors and to determine the drug receptor interactions. Objectives The main objectives of the experiment are as follows To measure the equilibrium dissociation constant for atropine at acetylcholine muscuranic receptors To demonstrate the reversible competitive antagonism of atropine at acetylcholine muscuranic receptors To determine the equilibrium dissociation constant (KB) for atropine at acetylcholine muscuranic receptors by using schild plot. Method Isolation and mounting of Guinea-pig ileum in organ bath Guinea-pig was first sacrificed and then the ileum was collected and transferred into physiological salt solution maintained at 370C. The food particles present in the ileum was expelled out through running Krebs solution through the lumen. Then tissue was tied with a thread at both the ends where one was tied to the mounting hook and the other was attached to the transducer. Preparation of serial dilutions of drug The drugs used in the experiment were acetylcholine (Ach) and atropine. To determine the simple competitive antagonism of atropine at Ach muscuranic receptors serial dilutions of Ach were carried out. Ach was given as 110-2M and from the above concentration of the drug the following concentrations were prepared to the organ bath concentration such as 110-6M, 310-6M, 110-7M, 310-7M, 110-8M, 310-8M, 110-9M and 310-9M Ach. Then atropine was diluted to 110-8M (organ bath) from the given 110-2M concentration. Determination of Organ bath concentration The volume of physiological salt solution (pss) was 20 ml, and each time the volume of drug introduced into organ bath was 20 µl.Therefore if 20 µl of 110-2M drug was introduced into the organ bath then it gives 110-5M organ bath concentration. Mathematical calculation of organ bath concentration: In organ bath we have 20ml of pss which is equal to 20103  µl of pss, if 20  µl of 110-2 M Ach was introduced then the organ bath concentration 20 µl→XM 20ml→10-2M = 20  µl x 10-2 M 20x 103  µl = 110-5M (organ bath concentration). The isolated guinea- pig ileum was mounted onto the organ bath and set up for recording isometric tension of the tissue using chart software in a Mac book. Step-1 Calibration of the experimental apparatus: The chart 5 software was calibrated and the sampling rate was adjusted to 10 samples per second with a maximum input voltage to 10 mV. The baseline was set to zero and then trace was started from the baseline zero then the force transducer was calibrated by placing 1 gram weight and after the calibration the trace produced was stopped for the moment to convert the units of tension into grams by selecting the trace produced previously. Step-2 Sensitisation of preparation: To check the viability of the tissue a response of suitable height was obtained by adding a little high concentration of the drug. Here in the experiment an appreciable recording was noted at 110-7M Ach. Step-3 The time cycle followed to construct a concentration- response curve was 0 seconds to add the drug concentrations 30 seconds to empty the organ bath and refill with fresh physiological salt solution 180 seconds next drug concentration was added to the organ bath. Concentration Response Curve: By making use of the above drug concentrations a concentration response curve was constructed according to the provided time cycle. 20  µl of 110-9M Ach was added into the organ bath at zero seconds at is allowed to stand for 30 seconds, then after 30 seconds the organ bath was emptied and refilled with pss. Pss was allowed to stand for 180 seconds. During the wash period if the peak does not return to the base then it was washed twice or thrice to make sure that all the drug dissociates from the receptors before the next addition of the other drug concentration. Each concentration was repeated twice or thrice until the two consecutive responses were reported with the same peak height. By following the procedure and time cycle, the concentration response curve was constructed with different concentrations of acetyl choline such as 110-9M,310-9M, 110-8M, 310-8M, 110-7M, 310-7M, 110-6M and 310-6M Ach (organ bath concentration). Step-4 Equilibration of Acetylcholine receptors with acetylcholine After step-2 the preparation was washed several times until the peak returned to the base line. Then atropine (110-8M organ bath concentration) was added to the preparation and then set aside for 40 minutes to allow atropine to equilibrate with acetylcholine muscuranic receptors. Step-5 Concentration response curve in the presence of atropine The concentration response curve with acetylcholine was repeated again in the presence of atropine by following the time cycle and procedure, which was same as same step 2.Therefore in step 3 with each addition of acetylcholine concentration atropine was added simultaneously. Step-6 Analysis: The graph pad prism in the Mac book was used to plot concentration response curves in the absence and presence of atropine. Log concentration (acetylcholine) Vs response in grams From the above plot EC 50 values of acetylcholine in the presence and absence of atropine were obtained. Then the distance between the two curves control and response for the atropine presence was denoted by r, where r was called as shift. The shift was calculated mathematically as r= EC 50 of response in the presence of atropine EC 50 of Ach in the absence of atropine From the value of the shift, schild plot was plotted as log concentration of atropine presence against log(r-1). From the schild plot the dissociation constant KB for atropine at acetylcholine muscuranic receptors was determined. Results: As explained above in the procedure serial dilutions of acetylcholine was added to the organ bath, where Ach has produced concentration dependent contractions of the guinea pig ileum as shown in the fig 1. Figure: 1 Trace showing contractions produced by serial dilutions of acetylcholine at muscuranic receptors. As shown in Figure 1 the serial dilutions of acetylcholine are added into the organ bath from 110-7M to 310-6M Ach. Here in the trace it was clearly shown that contractions produced by the acetylcholine have been increased with respect to the concentrations. In step-2 the preparation was washed and added with 110-8M atropine and set aside for 40 minutes to equilibrate the acetylcholine receptors. Figure: 2 Trace showing contractions produced by serial dilutions of acetylcholine at muscuranic receptors in the presence of atropine. In the trace it is clearly shown that, the contractions produced by serial dilutions of Ach from 110-8M to 310-4M in the presence of 110-8M atropine. When Trace 1 and Trace 2 are compared it is evident that the contractions produced by Ach alone (trace 1) were greater than the contractions produced Ach in the presence of atropine (trace 2) which proves the simple competitive antagonism by atropine at muscuranic receptors. A graph is plotted to the log concentration response curve produced by Ach alone against Ach in the presence of atropine. (graph is attatched to the report) From the graph it is known that with the increase in the concentration of Ach, response have been increased when compared to Ach in the presence of atropine and also there is a shift towards right which shows the simple competitive antagonism produced by atropine. From the results produced by Ach alone against Ach in the presence of atropine the fractional difference which is called as shift can be obtained as follows Mathematical Calculation shift r = EC50 of response after atropine (or) in the presence of atropine EC50 of control (or) Ach in the absence of atropine = 2.5110-6 = 8.36 3.0 x10-7 r-1 =8.36 -1=7.36 log(r-1)=log (7.36) =0.86 Partial dissociation constant (PKB) or PA2 is measured to confirm the simple competitive antagonism, where pKB values play an important role in classifying receptors. Therefore PKB =log(r-1) -log [atropine] =0.86 -log (110-8) =0.86 (-8) =0.86+ 8 =8.86 From the above results log EC50 values for control (Ach alone) and Ach in the presence of atropine were given as 3.0e-007 and 2.51e-006 respectively. This shows the molar concentration of Ach which produces 50% of the maximal possible response is higher than the molar concentration response produced by Ach in the presence of atropine. Figure 5: (Graph2) Schild plot If the antagonist is competitive, the dose ratio equals one plus the ratio of the concentration of antagonist divided by its Kd for the receptor. (The dissociation constant of the antagonist is sometimes called Kb and sometimes called Kd) A simple rearrangement gives: Here we have plotted a graph with log (antagonist) on the X-axis and log (dose ratio -1) on the Y-axis. If the antagonist has shown simple competitive antagonism then the slope should be 1.0, X-intercept and Y-intercept values should be both equal the Kd of the antagonist obtained. If the agonist and antagonist are competitive, the Schild plot will have a slope of 1.0 and the X intercept will equal the logarithm of the Kd of the antagonist. If the X-axis of a Schild plot is plotted as log(molar), then minus one times the intercept is called the pA2 (p for logarithm, like pH; A for antagonist; 2 for the dose ratio when the concentration of antagonist equals the pA2). The pA2 (derived from functional experiments) will equal the Kd from binding experiments if antagonist and agonist compete for binding to a single class of receptor sites. Figure 6: (table 2) Results for Schild Plot. From Figure 5 and 6 it is evident that no concentrations of atropine have showed competitive antagonism perfectly. Therefore from the above results it is known that the concentrations of atropine has not shown simple competitive antagonism fairly. Discussion: Reversible competitive antagonism: The binding of drug to a receptor is fully reversible which produces a parallel shift of the dose response curve to the right in the presence of an antagonist. The mechanism of action of acetylcholine at muscuranic receptors: In various gastrointestinal smooth muscles, acetylcholine and its derivatives produce contractions by activating muscuranic receptors. It is generally assumed that the M3 muscuranic receptor plays a key role in mediating this activity. The M3 receptor is coupled preferentially to Gq-type G proteins, resulting in the activation of phospholipase C (PLC) and the formation of ionositiol trisphosphate (IP3) and diacylglycerol (DAG) which are likely to participate in muscuranic receptor-mediated smooth muscle contractions. IP3 causes Ca2+ release from intracellular store and can also mobilize Ca2+ secondarily through Ca2+-sensitive or store-dependent mechanisms. DAG, via activation of protein kinase C, phosphorylates various proteins and can directly activate non selective cationic channels. Figure 7: Diagrammatic representation of calcium and smooth muscle contraction. From the above results the value of shift obtained was 0.378 which denotes the simple competitive antagonism produced by the concentration of atropine used (110-8 M).From the value of shift the pKB value was calculated as 8.4.If atropine has shown simple competitive antagonism then the value of pKB should be equal to 1-X intercept. Therefore pKB=1-X intercept =1-(-8.86) =9.86 We got value of pKB as 8.86.Therefore pKB is not equal to 1-X intercept. Therefore the concentration of atropine (110-8M organ bath concentration) used by our group has not shown simple competitive antagonism effectively. The literature value of pKB is given as approximately 9 and we have obtained the value of pKB as 8.86 which does not fit with literature value. Therefore from the above observations and results i can conclude that a little more high concentration of atropine may serve to produce complete simple competitive antagonism by atropine at acetylcholine muscuranic receptors.

What Factors Effect Student Cinema Attendance Media Essay

What Factors Effect Student Cinema Attendance Media Essay The main objective of this research is to determine factors that affect UEL students cinema-going behaviour. This report consist two main parts, Research Methodology and Finding and Analysis. At the end, a conclusion will be drawn out based on finding. 1.0 Literature Review Cinema-going refer to an action taken by individual to visit cinema for a movie screening, as those who visit cinema are called cinema-goers (Lipponen et al, 2003). Many researches have been done by researchers on cinema going behaviour in some country such as Australia (Henderson, 2007), Finland, Estonia, and Portugal (Lipponen et al, 2003). These studies focus on characteristics of cinema-goers that are similar between two or more different place. In order to determine what factors that affect cinema going behaviours, several areas of consumer behaviour have put into consideration. Knowledge Consumers knowledge refers to the amount of information that store within the memory of consumer on that particular product or services (Blackwell et al, 2001). What UEL students knew about that movie will affect their cinema-going behaviour. For examples, who is starring that movie? Who is the director? When the movie will be screen on local cinema? Attitudes Basically attitudes refer to what consumer prefer or like to consume. Cinema-goers usually go cinema watch movie is because of their favourite type movie screening. If that particular movie is dislike by him/her, most likely he/she wont go cinema. Perception Sometimes what consumer thought about that particular goods or services might affect their purchasing decision. Example action movies might suit to boys because of fighting scene but not suit for girl as they think that fighting is not good. 2.0 Methodology Research methods that going to apply is sampling method consist of survey throughout UEL students who study in International Business and Marketing course. Comparison between local and foreign students applied as different in background, education level, cinema censorship and perception toward a particular movie. Non-probability sampling applied where questionnaires were distributed based on their knowledge and personality. There are several limitations and advantages (Singleton et al, 1993) by using non-probability sampling. Limitations of non-probability sampling are unable to prevent bias of investigator on selection of participants and unable to predict the sampling error or sample precision. Advantages are less expensive and easy to collect with high respond rate. Primary data Questionnaire consist of 90 sets were distributed among UEL students and 80 sets responded. The questionnaire consists of 3 sections with total of 18 where most are close-ended questions (referring to Appendix 1). Total Responded Rate = 80 / 90 * 100% = 88.89% Besides that, focus group and personal interview have been used to collect primary data. This method apply is because focus group provide more information compare to observation (Morgan, 1997). Besides that, result can be obtained in fast and easy way. Yet some may not be able to join in the focus group due to distance and not easy to locate the right person (Morgan, 1997). Detailed explanation on these two methods stated on Appendix 2. Personally interview was carried out in order to obtain more accurate data beside questionnaire and focus group. Two respondents with different background and knowledge level were selected as they able to provide different answers which are not generalise. Yet limitation of personal interview is bias may occurred when selecting respondents and that respondents may not have the time for interview. 3.0 Finding and Analysis Based on Table 1, questionnaire respondents of 80 divided into two groups, 46 local students and 34 foreign students. All those respondents are UEL students. Question 2: What day in a week you likely will visit to cinema? Based on the finding from questionnaire, Saturday ranked as the first choose of day to go cinema for a movie with a total of 43 (27.56%), both local and foreign, students. While Wednesday ranked as second choice of UEL students with 37 (23.72%) students. Friday and Sunday follow after second ranking. Values of percentage refer to Table 2.1. From the overall finding, we conclude that local and foreign students prefer to watch movie on weekends. Result from focus group has found similarity to questionnaire where majority of member prefer to watch movie on Saturday and Wednesday. One of them stated that Wednesday they able to purchase the ticket using student price. The others stated Saturday is more suitable as their boyfriend/girlfriend/classmates doesnt have any class where they usually unable to meet during weekdays. Yet from personal interview, local respondent choose weekdays as weekends price for ticket is much expensive. Foreign respondent stated that weekends will not suitable as too crowded. Question 3: What types of movie genre you prefer to watch at cinema? Through questionnaire, both local and foreign students prefer to watch action movies in cinema with a total of 54 (20.69%) respondents. While comedy (46 respondents, 17.62%) and romance (30 respondents, 11.49%) following the back. Dance/musical movies found as the lowest pick (20 respondents, 7.66%) and hence being ranked as likely unwelcome movies among local and foreign students. Values of percentage can be found in Table 3.1. Focus group show same result where majority of them are like to watch action movie. Reasons are have different kind of feeling, more excited, sound system made it more real, love to watch martial arts and so on. One of them stated that romance movies are suitable to watch together with their spouse. None of them prefer to watch dance/musical movies at cinema. Personal interview indicated that action movies are their first choice if they wish go cinema. One of respondents says that dance/musical movies are not worth to watch at cinema. Hence conclusion is movie genre can affect UEL student cinema-going behaviour where the movie must in the preference of them. Question 4: What language of movie that you preferred to watch? Based on the result of questionnaire, both local and foreign students prefer to watch English language movies (68 respondents, 57.63%). Chinese language movies are the second higher (38 respondents, 32.2%). Certain respondents have chosen other languages such as Japanese, Korean, and Hindu. From focus group, all respondents choose English language movies. Reasons are they want to improve/strengthen their language in English, much better compare with other types, learn the way they speak and etc. Result from personal interview also supporting finding in questionnaire as they found that their spoken language in English is bad and want to improve by learning how they speak. Local respondent stated that English movies are much more excited that other language movie. Question 5: Usually you go to cinema with whom? From questionnaires result, we found that majority of local and foreign UEL students go cinema with their friends (75 respondents, 64.66%). Spouse (22 respondents, 18.97%) and family (13 respondents, 11.21%) following after friends. This situation occurred as majority of respondents prefer to watch action movies and their girlfriend unwilling to follow them. Focus groups respondents also providing similar answer as questionnaire where they feel that a group of friends go for movie watching is part of their entertainment, fulfil their social needs as illustrated in Maslows Hierarchy of Needs (refer to Appendix 3). Result from personal interview show different respond. Local respondent spend much of the time watch movies with his girlfriend while foreign respondent prefer to watch movies with friends as his spouse didnt follow him come here to study. Question 8: Based on your last cinema going experience, please the following statement. (1 Very Poor, 2 Poor, 3 Fair, 4 Good, 5 Very Good) Respondents in questionnaire choose that environment on previous visiting to cinema are good. Majority of local and foreign students (46 respondents which is the highest among three factors, 57.5%) are satisfied with the environment such as seats, screening, sound system and others. This shows that students satisfaction on cinemas environment can be important factor in affecting cinema-going behaviour. At the same time, focus group provide more reasons to support result in questionnaire as all respondents are satisfied with overall environment during last visit to cinema. One of the respondents stated that every single cinema company is competing with each other by providing better environment and services especially Golden Screen Cinema (GSC). The others say they will visit the same cinema again in the future because that particular cinema can satisfied them. Respondents in personal interview stated that environment play less role when determine cinema-going where location is the most important. Even the closer cinema to his house didnt provide good environment, he will insist to go there. Question 9: How do you become aware of the new movies screening in the local cinema? Through questionnaire, we can see that majority of local and foreign UEL students become aware of new movies and obtain their information through newspaper and friends recommendations (both with the same respondents rate of 49, 24.87%). Besides that, online website (36 respondents, 18.27%) is another place where they can get new movies information from. Focus groups respondents also stated that they usually obtain information from their friends or through newspaper. Seldom watch movie trailer before going to cinema and watch that particular movie. Online website usually used for e-reservation purpose only. Personal interview also found that local and foreign UEL students also obtain their information by friends recommendation and newspaper. Respondents stated that movies that rated best or good by friends should be fine with them. Therefore they will go cinema and watch that movies. We able to conclude that friends influence can affect their cinema-going behaviour. Question 10: Please indicate what reasons that discourage you from going cinema. Result from questionnaire show that location (53 respondents, 42.06%) is the main factor that affects their cinema-going behaviour, both local and foreign students. Ticket price ranked as second factor with 28 respondents and 22.22% while public transportation (21 respondents, 16.67%) follows at the back. Those respondents choose others provide reason such as environment and availability of new movies in that cinema. In contrast focus group provides different answer from questionnaire where majority of respondents stated that location is not their concern. They stated that environment is their main concern of going cinema even that cinema located far from their living place. Minority say that public transportation must available as they dont have own transportation. But personal interview show that location is their main concern as they need to travel with their own transport. Sometime traffic is too crowded until they feel tired if that cinema located far from their house. Environment will fall under consideration when going cinema. Question 12: Does the availability of movie viewing alternative such as DVD/VCD/Online streaming discourage you from going cinema? Based on questionnaire result, we may conclude that majority of the respondents will not be discouraged to go cinema even there is availability of movie viewing alternative. The result accumulated with 43 respondents or 53.75% of total respondents. Focus group show supportive result where all respondents choose that movie viewing alternative will not be the factor from discouraging them from going cinema. Respondents say that watching movie at cinema will have different feeling from watching VCD/DVD at home. Besides that environment in cinema can allow couple to strengthen their relation according to respondent. Moreover personal interview show the similar result as questionnaire and focus group. Both local and foreign students will not bought VCD/DVD/Online streaming as they want to be the first person to watch the movie in cinema. Besides that, if the movie is good then they can recommend to their friends. 4.0 Conclusion When preparing the report, comparison is made between local students and foreign students. Through the research, we can conclude that both local and foreign UEL students prefer to watch movies with their friends. Besides that, majority of them go to cinema based on their satisfaction on several areas such as environment, sound system, screen and etc. Yet local students obtain their information for that particular movie through their friends recommendation while foreign students prefer to get information through newspaper. However, this research topic required a deeper analysis to a wider range of factors and keeps up to date where human behaviour will change from time-to-time. (2,057 words) 5.0 Appendixes Survey form sample (Appendix 1) University of East London Stamford College Petaling Jaya Lot 7A, Jalan 223, Seksyen 14, 46100 Petaling Jaya, Selangor Tel: (+603) 79563188 Website: www.stamford.edu.my Dear Sir/Madam, A research has been conducted in order to determine what factors that affect UEL students cinema-going behaviour. Therefore survey form was distributed among UEL students. Information will be used for education and research purpose only. All information disclosed in this survey form will not be distributed or re-used by third party. Please kindly answer ALL questions listed in the survey form. Thank you. Section A: Demographic (Please read the question carefully and place à ¢Ã‹â€ Ã… ¡ on those answer that most appropriate) Gender: Male Female Age: Below 20 21 23 24 26 27 29 Above 30 Nationality: Malaysian China Indonesian Others: _______________ Race: Malay Chinese Indian Others: _______________ Marital status: Single Married Divorced Highest education level: Primary school Secondary school A Level College University *UEL ID: ____________________ (Year ___ Semester ___) * Field indicated to fill in for future data keeping. Section B: How often do you visit cinema? Everyday 3 4 times per week Once a month Once per week Never visit (Go to Section C) What day in a week you likely will visit to cinema? Monday Tuesday Wednesday Thursday Friday Saturday Sunday What types of genre you prefer to watch at cinema? (Continued Pg 3) Animation 3D Horror Romance Action Comedy Sci-Fi Dance/Musical What language of movie that you preferred to watch? English Chinese Tamil Others: ______________ Do you prefer to watch movie similar to drama? (eg, High School Musical1, 2 and 3) Yes No Usually you go to cinema with whom? (Can choose more than one answer) Family Friends Spouse Alone How much are you prepared to spend to purchase a cinema ticket? RM 5 RM 10 RM 11 RM 16 RM 17 RM 22 Above RM 22 Based on your last cinema going experience, please rate every statements stated below: Lighting Lighting(1 Very poor, 2 Poor, 3 Fair, 4 Good, 5 Very good) à ¢Ã¢â‚¬  Ã‚  1 2 3 4 5 à ¢Ã¢â‚¬  Ã¢â‚¬â„¢ Clear screen Clear screen à ¢Ã¢â‚¬  Ã‚  1 2 3 4 5 à ¢Ã¢â‚¬  Ã¢â‚¬â„¢ Air condition Air condition à ¢Ã¢â‚¬  Ã‚  1 2 3 4 5 à ¢Ã¢â‚¬  Ã¢â‚¬â„¢ Seats setting Seats setting à ¢Ã¢â‚¬  Ã‚  1 2 3 4 5 à ¢Ã¢â‚¬  Ã¢â‚¬â„¢ Sound system Sound system à ¢Ã¢â‚¬  Ã‚  1 2 3 4 5 à ¢Ã¢â‚¬  Ã¢â‚¬â„¢ How do you become aware of the new movies screening in the local cinema? (Continue Section C) Magazines Friends recommendation Online website Newspaper Cinema centre Broadcasting Section C: Please indicate what reasons that discourage you from going cinema (Can choose more than one answer). Price Cinema location Public transportation Promotion Other (Please specify: _________________________________________________) Please rank the following cinema companies from most popular to not popular based on your opinions. (1 Most popular, 2 Popular, 3 Fair, 4 Less popular, 5 Not popular) GSC TGV Cathay Cineplex MBO Lotus Five Star Does the availability of movie viewing alternative such as DVD/VCD/Online streaming discourage you from going cinema? Yes No Thank you for helping in this survey. Appendix 2 Focus Group Discussion This group consists of seven members, both local and foreign UEL students. Their personal information was not collected as each person prefer to remain anonymous in this research. Below is the result from the discussion: Usually you prefer to watch movies on which day? Why? Wednesday. Promotion. Student price. Not so crowded as weekends. Friday. No class on Friday for most of the students. Can spend more time with girlfriend/boyfriend. Saturday. Weekends price cheaper than weekdays. Usually not class for their spouse. What movies genre that you always watch at cinema? Action movies Romance movies (usually with spouse) 3D movies yet due to newly introduce therefore seldom watch by students. Horror movies What type of movies language that you prefer to watch at cinema? Why? English. Strengthen their language. Improve their speaking skill. More better if compare with other language Adopt the correct way to speak English. Forced by lecturer to watch English movies. Usually you go to cinema with whom? Why? Friends. Part of their life. To entertain friends because they ask for a movie. Can share opinions after watching movies. Spouse. Being forced. Improve relationship. Do you satisfied with last experience to cinema in term of seat, sound system, and screen? Will you go to that particular cinema again? Satisfied with those three factors. Yes because GSC provide the best environment to their customers. Satisfied. Now every cinema companies are competing in term of environment in order to booths up their sales. Willing to visit that cinema again. How do you become aware of new movies screening in cinema? Newspaper. Online website (usually for reserve purpose) Friends recommendation Does public transportation affect your cinema-going behaviour? No. Usually have own transportation. Major concern when dont have own transportation. Does location will affect your cinema-going behaviour? Yes. Sometime that cinema is located far away from their house. Stuck in traffic jam will feel exhausted and eliminate the mood to watch movie. Usually price will discourage you from going cinema? No. As long the price is within reasonable price range. No. To enjoy different feeling. Yes. Not affordable to purchase expensive ticket. Does alternative of movie viewing such as DVD or online streaming will discourage you from going cinema? No. That kind of feeling which obtained through watching at cinema is different from watching movie at home. No. Able to have more private space with spouse. Personal Interview Respondents personal information: L: Local student (1116421) F: Foreign student (1116608) Date: 12 April 2010 Duration: 45 minutes Can you tell me in which day of a week that you always go watch movies? L: I always watch movies on weekends especially on Saturday because I able to save cost compare to weekdays. F: Prefer to watch on weekdays oh because I can use my student card to get student price on Wednesday. Then what movies genre that you always watch at cinema? L: Action movies will be my first choose because the way they fight make me feel excited. F: Action movies. I dont like to watch dance/musical movies because is very boring and not attractive to me. What language movies that you always watch at cinema? L: English movies. More excited and adventure compare to other type of language. F: English movies because I am weak in speaking English when communicating with friends or lecturer. So I want to learn how to speak English. You usually go to cinema with whom? L: Friends. To entertain them. But majority of the time will go on date with girlfriend as normal day is study day and unable to spend more time with her. F: Friends. No choice because my boyfriend is not with me at Malaysia. Do environment factors affect your cinema going behaviour? Factors such as seat, sound system and screen. L: Of course not. Fuel price becoming more expensive than before so nearest cinema will be my choice. F: No. As long that I able to be with my friends, other factors will not be my concern. How you get your information about new movies at cinema? L: Through my friends and sometime from newspaper. F: Friends recommendation and newspaper. Usually online website was used to book ticket only. Does distance from your house to cinema is another factor discouraging you from going cinema? L: Yes. More nearest to my house, more likely I will choose that cinema. F: Yes. Sometime when the traffic is crowded then I might late for that movie. Then how about public transportation? L: No. Usually I will drive my car. F: No. My friends will come and fetch me. Will you pay high price for a movie? L: Depend on what movie. If that movie is my favourite then I wont mind spending high price but must be reasonable. F: Usually wont because I have limited budget to spend on every week. Will you buy DVD or go online to watch movie instead of going cinema? L: No. That kind of excitement cannot found if watch at home. (Some reasons have been removed due to personal reason) F: No. As long I can be with my friend, I can go watch movie even I watch that movie for more than two times. Appendix 3 Maslows Hierarchy of Needs, introduced by Abraham Maslow, a famous psychologist, divine into five areas: Physiological Needs, Security Needs, Social Needs, Esteem Needs, Self-actualisation needs. In Social Needs stage, human want to have a sense of belonging, being love or loving. Involved in relationship such as friendship, romance, families can help human being to fulfil their needs for companionship and acceptance (Maslow, 1970).

Blame :: essays research papers

  Ã‚  Ã‚  Ã‚  Ã‚  Are some people more to blame for a crime then others and if so why? This is a question which many people wonder about today. I think the answer is yes. People who are brought up in a certain way are more likely to commit a certain crime than others. In he following I will consider why certain people are more to blame then others for the crimes that they commit.   Ã‚  Ã‚  Ã‚  Ã‚  Before looking at the issue of if some people are more to blame than others we must first look the reasons in which people may commit crimes and the type of crimes. There are a variety of reasons for a person to commit a crime including greed, to be famous, need for money, pure hate, and insanity. The crimes in which they commit range from murder, robberies, or rape.   Ã‚  Ã‚  Ã‚  Ã‚  After looking at reasons why and the types of crimes it is now possible to look at the larger issue at hand. If a person is poor and they are performing a robbery to get some money to feed their baby should they be more to blame than someone who is rich but performing the same robbery because they are greedy. There is no right answer to this but I think that the person who is robbing the store to help his kid is less to blame. I say this because even though the person is poor it is not always his fault. He may not be able to get money for his baby but would still feels the need to provide for it. This is what forces him to rob the store. I feel people should look at him with a bit of compassion because the reason that he was committing the crime was not a selfish one but one that benefits others. On the other hand the rich guy who robbed the store cause he was greedy should be help more accountable for his crime. Since he is rich and did not need the money and onl y committed the crime because of his own selfishness he is more to blame.   Ã‚  Ã‚  Ã‚  Ã‚  You might say why should the blame be divided differently between the two people if in fact they did commit the same crime. Now it is true that they are both supposed to be equal but are they really truly equal. How can we say that a poor person is equal to a rich one?